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Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy.
- Source :
-
Molecular Immunology . Oct2013, Vol. 55 Issue 3/4, p283-291. 9p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] We reported Egr2 as a central transcriptional regulator of T cell anergy induction. [•] Microarray and ChIP-Seq analyses were conducted to investigate Egr2 transcriptome. [•] 49 new targets were identified to be directly regulated by Egr2 in anergic cells. [•] Egr2 regulates several cell surface and secreted molecules in anergic cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01615890
- Volume :
- 55
- Issue :
- 3/4
- Database :
- Academic Search Index
- Journal :
- Molecular Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 89089643
- Full Text :
- https://doi.org/10.1016/j.molimm.2013.03.006