Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy.

Highlights: [•] We reported Egr2 as a central transcriptional regulator of T cell anergy induction. [•] Microarray and ChIP-Seq analyses were conducted to investigate Egr2 transcriptome. [•] 49 new targets were identified to be directly regulated by Egr2 in anergic cells. [•] Egr2 regulates several cell surface and secreted molecules in anergic cells. [ABSTRACT FROM AUTHOR]