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Role of β-Catenin in regulating the balance between TNF-α- and Fas-induced acute liver injury.
- Source :
-
Cancer Letters . Jul2013, Vol. 335 Issue 1, p160-167. 8p. - Publication Year :
- 2013
-
Abstract
- Abstract: β-Catenin plays many critical roles during various liver physiological and pathological processes. However, the role of β-Catenin in acute liver failure remains unclear. Using hepatocyte specific β-Catenin knockout mice, we found that loss of β-Catenin in hepatocyte significantly reduced GalN/LPS-induced liver damage and hepatocyte apoptosis, but exacerbated Jo2-mediated liver injury. Mechanistically, the dual effects of β-Catenin attributes on its function of inhibiting NF-κB signaling, which aggravates oxidative stress but decreases Fas expression under injury conditions. In conclusion, β-Catenin plays an important role in regulating the balance between TNF-α and Fas-induced liver injury via its effect on NF-κB. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 335
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 89104564
- Full Text :
- https://doi.org/10.1016/j.canlet.2013.02.008