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Levels of supramolecular chirality of polyglutamine aggregates revealed by vibrational circular dichroism.

Authors :
Kurouski, Dmitry
Kar, Karunakar
Wetzel, Ronald
Dukor, Rina K.
Lednev, Igor K.
Nafie, Laurence A.
Source :
FEBS Letters. Jun2013, Vol. 587 Issue 11, p1638-1643. 6p.
Publication Year :
2013

Abstract

Highlights: [•] PolyQ fibril aggregates exhibit enhanced VCD and supramolecular chiral organization that differ from all previously observed amyloid fibrils. [•] Q ⩾35 aggregates show a further enhanced level of supramolecular chiral organization compared to Q ⩽30 aggregates. [•] Q ⩾35 and Q ⩽30 fibril aggregates exhibit the same secondary structure and VCD intensity pattern. . [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00145793
Volume :
587
Issue :
11
Database :
Academic Search Index
Journal :
FEBS Letters
Publication Type :
Academic Journal
Accession number :
89107765
Full Text :
https://doi.org/10.1016/j.febslet.2013.03.038