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Recent advances in microRNA-mediated gene regulation in chronic lymphocytic leukemia.
- Source :
-
Clinical Biochemistry . Jul2013, Vol. 46 Issue 10/11, p901-908. 8p. - Publication Year :
- 2013
-
Abstract
- Abstract: Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world and is a very clinically heterogeneous disease for which better prognostic biomarkers are needed. Current prognostic markers exhibit both biological and technical limitations. MicroRNAs (miRNAs) are small endogenous, non-coding 22-nucleotide regulatory RNAs that have been shown to modulate hematopoietic lineage differentiation and play important gene-regulatory roles in disease processes. In this manuscript, we review miRNA biology and the association of specific miRNAs with CLL. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00099120
- Volume :
- 46
- Issue :
- 10/11
- Database :
- Academic Search Index
- Journal :
- Clinical Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 89113967
- Full Text :
- https://doi.org/10.1016/j.clinbiochem.2013.03.007