Two p53-related metabolic regulators, TIGAR and SCO2, contribute to oroxylin A-mediated glucose metabolism in human hepatoma HepG2 cells.

Highlights: [•] Oroxylin A inhibited aerobic glycolysis via glucose uptake and lactate generation. [•] Oroxylin A exerted little influence on the oxygen consumption. [•] TIGAR and SCO2 are the key effectors in oroxylin A-mediated glucose metabolism. [•] Oroxylin A induced p53 accumulation, modulated its stability and activity. [•] P53 partly contributes to oroxylin A-induced upregulation of TIGAR and SCO2. [ABSTRACT FROM AUTHOR]