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Two p53-related metabolic regulators, TIGAR and SCO2, contribute to oroxylin A-mediated glucose metabolism in human hepatoma HepG2 cells.
- Source :
-
International Journal of Biochemistry & Cell Biology . Jul2013, Vol. 45 Issue 7, p1468-1478. 11p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] Oroxylin A inhibited aerobic glycolysis via glucose uptake and lactate generation. [•] Oroxylin A exerted little influence on the oxygen consumption. [•] TIGAR and SCO2 are the key effectors in oroxylin A-mediated glucose metabolism. [•] Oroxylin A induced p53 accumulation, modulated its stability and activity. [•] P53 partly contributes to oroxylin A-induced upregulation of TIGAR and SCO2. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13572725
- Volume :
- 45
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- International Journal of Biochemistry & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 89114591
- Full Text :
- https://doi.org/10.1016/j.biocel.2013.04.015