Friedel–Crafts cyclization of tertiary alcohols using bismuth(III) triflate.

Authors :: Nammalwar, Baskar
Bunce, Richard A.
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Aug2013, Vol. 54 Issue 32, p4330-4332. 3p.
Publication Year :: 2013
Abstract: Abstract: Bismuth(III) triflate [Bi(OTf)3] has been developed as an efficient and mild catalyst for intramolecular Friedel–Crafts cyclizations of tertiary alcohols to prepare disubstituted tetrahydronapthalenes, chromans, thiochromans, tetrahydroquinolines, and tetrahydroiso-quinolines. The method represents a unified strategy to synthesize a variety of ring systems from tertiary alcohols using a common Lewis acid. [Copyright &y& Elsevier]

Subjects :: *FRIEDEL-Crafts reaction
*RING formation (Chemistry)
*ALCOHOLS (Chemical class)
*BISMUTH compounds
*CHEMICAL synthesis
*QUINOLINE

Language :: English
ISSN :: 00404039
Volume :: 54
Issue :: 32
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 89136675
Full Text :: https://doi.org/10.1016/j.tetlet.2013.06.026