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A pharmacology-based comparison of the activity of albendazole and flubendazole against Echinococcus granulosus metacestode in sheep.
- Source :
-
Acta Tropica . Sep2013, Vol. 127 Issue 3, p216-225. 10p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] ABZ and FLBZ efficacy against cystic echinococcosis (CE) was assessed. [•] ABZ metabolites reached a higher systemic exposure compared to FLBZ/metabolites. [•] Both ABZ and FLBZ markedly decreased protoscoleces’ vitality/viability. [•] Hepatotoxicity due to the long standing treatment was not observed. [•] Enhancing FLBZ bioavailability may improve the efficacy against CE. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0001706X
- Volume :
- 127
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Acta Tropica
- Publication Type :
- Academic Journal
- Accession number :
- 89137351
- Full Text :
- https://doi.org/10.1016/j.actatropica.2013.05.004