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Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target α5 integrin in colon cancer cells.
- Source :
-
Cancer Letters . Aug2013, Vol. 336 Issue 2, p307-318. 12p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] Inhibition of α5β1 integrin expression or functions alters HCT116 cell survival. [•] Nutlin-3a affects α5 integrin expression through p53 activation. [•] A negative crosstalk between α5β1 integrin and p53 wt has been identified. [•] Reactivation of p53 above a threshold is of interest as a therapeutic option for colon tumors overexpressing α5 integrin. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 336
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 89137502
- Full Text :
- https://doi.org/10.1016/j.canlet.2013.03.018