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Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction.
Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction.
- Source :
-
Journal of Neurochemistry . Aug2013, Vol. 126 Issue 3, p400-414. 15p. 2 Color Photographs, 1 Chart, 7 Graphs. - Publication Year :
- 2013
-
Abstract
- Tumor necrosis factor receptor-associated factor 5 ( TRAF5) is an adaptor protein of the tumor necrosis factor ( TNF) receptor superfamily and the interleukin-1 receptor/Toll-like receptor superfamily and plays important roles in regulating multiple signaling pathways. This study was conducted to investigate the role of TRAF5 in the context of brain ischemia/reperfusion (I/R) injury. Transient occlusion of the middle cerebral artery was performed on TRAF5 knockout mice ( KO), neuron-specific TRAF5 transgene ( TG), and the appropriate controls. Compared with the WT mice, the TRAF5 KO mice showed lower infarct volumes and better outcomes in the neurological tests. A low neuronal apoptosis level, an attenuated blood-brain barrier ( BBB) disruption and an inhibited inflammatory response were exhibited in TRAF5 KO mice. TRAF5 TG mice exhibited an opposite phenotype. Moreover, the Akt/FoxO1 signaling pathway was enhanced in the ischemic brains of the TRAF5 KO mice. These results provide the first demonstration that TRAF5 is a critical mediator of I/R injury in an experimental stroke model. The Akt /FoxO1 signaling pathway probably plays an important role in the biological function of TRAF5 in this model. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223042
- Volume :
- 126
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Neurochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 89149706
- Full Text :
- https://doi.org/10.1111/jnc.12207