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Inhibition of α-toxin production by subinhibitory concentrations of naringenin controls Staphylococcus aureus pneumonia.
- Source :
-
Fitoterapia . Apr2013, Vol. 86, p92-99. 8p. - Publication Year :
- 2013
-
Abstract
- Abstract: Staphylococcal pneumonia provoked by methicillin-resistant Staphylococcus aureus (MRSA) is a life-threatening infection in which α-toxin is an essential virulence factor. In this study, we investigate the influence of naringenin on α-toxin production and further assess its therapeutic performance in the treatment of staphylococcal pneumonia. Remarkably, the expression of α-toxin was significantly inhibited when the organism was treated with 16μg/ml of naringenin. When studied in a mouse model of S. aureus pneumonia, naringenin could attenuate the symptoms of lung injury and inflammation in infected mice. These results suggest that naringenin is a promising agent for treatment of S. aureus infection. [Copyright &y& Elsevier]
- Subjects :
- *PNEUMONIA prevention
*STAPHYLOCOCCAL disease prevention
*ALTERNATIVE medicine
*ANIMAL experimentation
*BIOLOGICAL assay
*BIOLOGICAL models
*BIOPHYSICS
*PHYSICAL & theoretical chemistry
*EPITHELIAL cells
*FLAVONOIDS
*HEMOLYSIS & hemolysins
*RESEARCH methodology
*MICE
*MICROBIAL sensitivity tests
*POLYMERASE chain reaction
*RESEARCH funding
*T-test (Statistics)
*WESTERN immunoblotting
*PLANT extracts
*REVERSE transcriptase polymerase chain reaction
*DATA analysis software
*DESCRIPTIVE statistics
*IN vitro studies
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 86
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 89192788
- Full Text :
- https://doi.org/10.1016/j.fitote.2013.02.001