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Biotransformation of ursolic acid by Syncephalastrum racemosum CGMCC 3.2500 and anti-HCV activity.

Authors :
Fu, Shao-bin
Yang, Jun-shan
Cui, Jin-long
Sun, Di-An
Source :
Fitoterapia. Apr2013, Vol. 86, p123-128. 6p.
Publication Year :
2013

Abstract

Abstract: Microbial transformation of ursolic acid (UA, 3β-hydroxy-urs-12-en-28-oic acid, 1) by filamentous fungus Syncephalastrum racemosum CGMCC 3.2500 was conducted. Five metabolites 3β, 7β, 21β-trihydroxy-urs-12-en-28-oic acid (2); 3β, 21β-dihydroxy-urs-11-en-28-oic acid-13-lactone (3); 1β, 3β, 21β-trihydroxy-urs-12-en-28-oic acid (4); 3β, 7β, 21β-trihydroxy-urs-1-en-28-oic acid-13-lactone (5); and 21-oxo-1β, 3β-dihydroxy-urs-12-en-28-oic acid (6) were afforded. Elucidation of the structures of these metabolites was primarily based on 1D and 2D NMR and HR-MS data. Metabolite 2 was a new compound. In addition, the anti-HCV activity of compounds 1–6 was evaluated. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
0367326X
Volume :
86
Database :
Academic Search Index
Journal :
Fitoterapia
Publication Type :
Academic Journal
Accession number :
89192792
Full Text :
https://doi.org/10.1016/j.fitote.2013.02.007