Back to Search
Start Over
Anti-allergic action of buckwheat (Fagopyrum esculentum Moench) grain extract
- Source :
-
International Immunopharmacology . Jan2003, Vol. 3 Issue 1, p129. 8p. - Publication Year :
- 2003
-
Abstract
- The anti-allergic action of buckwheat grain extract (BGE) was investigated using rodent experimental models. The oral, intraperitoneal and intradermal administration of BGE significantly inhibited the compound 48/80-induced vascular permeability documented by Evans blue extravasation. In addition, BGE showed potent inhibitory effect on passive cutaneous anaphylaxis (PCA) activated by anti-dinitrophenyl (DNP) IgE when orally administered. In an in vitro study, BGE revealed to possess inhibitory potential on the compound 48/80-induced histamine release from rat peritoneal mast cells (RPMC). Moreover, BGE inhibited the IL-4 and TNF-α mRNA induction by PMA and A23187 in human leukemia mast cells, HMC-1. Taken together, these results suggest that anti-allergic action of BGE may be due to the inhibition of histamine release and cytokine gene expression in the mast cells. [Copyright &y& Elsevier]
- Subjects :
- *BUCKWHEAT
*RODENTS
*ANAPHYLAXIS
Subjects
Details
- Language :
- English
- ISSN :
- 15675769
- Volume :
- 3
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- International Immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 8927291
- Full Text :
- https://doi.org/10.1016/S1567-5769(02)00261-8