Transcellular transport of aconitine across human intestinal Caco-2 cells.

Highlights: [•] The bidirectional transports of aconitine across Caco-2 cells were investigated. [•] The influx of aconitine was temperature-, pH- and Na+-dependent. [•] The uptake of aconitine may be mediated by a sodium-dependent glucose transporter. [•] The efflux of aconitine was temperature- and pH-dependent, but Na+-independent. [•] The active efflux of aconitine was mediated mainly by P-gp. [Copyright &y& Elsevier]