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Will the idiotypic network help to solve natural tolerance?
- Source :
-
Trends in Immunology . Feb2003, Vol. 24 Issue 2, p53. 2p. - Publication Year :
- 2003
-
Abstract
- A recent paper on immunity and tolerance to antigenic determinants on antibody variable-regions (idiotypes) brings back to light the potential of idiotypic interactions among antibodies, B cells and T cells in the regulation of specific immune activities. The functional significance of idiotypic regulation has been established in a variety of systems, both concerning the establishment of ‘pre-immune’ diversity repertoires as well as the clonal regulation of immune responses to foreign and self-antigens. Also, recently the requirement for ‘dominant’ regulatory mechanisms in natural tolerance has received increasing support. It might thus be fruitful to evaluate the possibility that an idiotypic network has a fundamental role in the operation of the regulatory T cells that establish and maintain self-tolerance. [Copyright &y& Elsevier]
- Subjects :
- *IMMUNITY
*IMMUNOGLOBULIN idiotypes
*B cells
*T cells
Subjects
Details
- Language :
- English
- ISSN :
- 14714906
- Volume :
- 24
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Trends in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 8927320
- Full Text :
- https://doi.org/10.1016/S1471-4906(02)00035-2