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Antiepileptic effect of dimethyl sulfoxide in a rat model of temporal lobe epilepsy.

Authors :
Carletti, Fabio
Ferraro, Giuseppe
Rizzo, Valerio
Cannizzaro, Carla
Sardo, Pierangelo
Source :
Neuroscience Letters. Jun2013, Vol. 546, p31-35. 5p.
Publication Year :
2013

Abstract

Highlights: [•] Different doses of DMSO are tested in 3 groups of rats after 5 stable epileptic discharges in the DG. [•] 100% and 50% solutions of DMSO with a dose dependent effect reduce the epileptic activity. [•] We infer that DMSO dampens excitotoxic phenomena reducing the glutamatergic transmission. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03043940
Volume :
546
Database :
Academic Search Index
Journal :
Neuroscience Letters
Publication Type :
Academic Journal
Accession number :
89296854
Full Text :
https://doi.org/10.1016/j.neulet.2013.04.031