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2281 – Psychosocial and overall effectiveness of aripiprazole once-monthly vs. placebo once-monthly for maintenance treatment in schizophrenia.
- Source :
-
European Psychiatry . Jan2013, Vol. 28, p1-1. 1p. - Publication Year :
- 2013
-
Abstract
- Objective: Evaluate the effectiveness of investigational aripiprazole once-monthly (ARI-OM) for maintenance treatment in schizophrenia. Methods: Detailed methodology has been published previously1. Briefly, the study consisted of 4 phases: oral conversion to aripiprazole (Phase 1); oral aripiprazole stabilization (Phase 2); ARI-OM stabilization (Phase 3), with co-administration of oral aripiprazole for the first 2 weeks; and an ARI-OM maintenance phase (Phase 4). Effectiveness assessments included Investigator's Assessment Questionnaire (IAQ) scores, a scale that evaluates effectiveness of current treatment vs. pre-trial medication, where a negative change in score signals improvement, and Personal and Social Performance (PSP) scale scores, where negative change in score signals worsening. Results: 710 patients entered Phase 2, 576 Phase 3 and 403 Phase 4 (ARI-OM=269, placebo once-monthly [placebo- OM]=134). Mean IAQ Total scores remained stable in Phase 2 (31.3) and Phase 3 (30.6). During Phase 4, the mean change in IAQ Total score was +1.3 for ARI-OM vs. +3.8 for placebo-OM (p<0.0001). Mean changes in PSP Total scale scores showed improvement during Phase 2 (3.0) and Phase 3 (2.6). Mean change in PSP scores during Phase 4 showed greater functional stability with ARI-OM (−1.7) compared with placebo-OM (−6.2) (p=0.0002 vs. placebo-OM). Conclusions: Improvements in effectiveness, as assessed by the IAQ and PSP Total scale scores, in the Phases 2 & 3 were maintained in Phase 4 for ARI-OM compared with placebo-OM. Treatment with ARI-OM improved symptoms, overall response to treatment and functioning. [Copyright &y& Elsevier]
- Subjects :
- *PSYCHOSOCIAL factors
*ARIPIPRAZOLE
*PLACEBOS
*SCHIZOPHRENIA
*DRUG utilization
Subjects
Details
- Language :
- English
- ISSN :
- 09249338
- Volume :
- 28
- Database :
- Academic Search Index
- Journal :
- European Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 89341266
- Full Text :
- https://doi.org/10.1016/S0924-9338(13)77141-4