Measurement of free carnitine and acylcarnitines in plasma by HILIC-ESI-MS/MS without derivatization.

Authors :: Peng, Minzhi
Liu, Li
Jiang, Minyan
Liang, Cuili
Zhao, Xiaoyuan
Cai, Yanna
Sheng, Huiying
Ou, Zhiying
Luo, Hong
Source :: Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. Aug2013, Vol. 932, p12-18. 7p.
Publication Year :: 2013
Abstract: Highlights: [•] A method for measurement of acylcarnitines has been developed using HILIC-MS/MS. [•] Acylcarnitines were detected without derivatization. [•] IDA experiment was performed to explore fragment pattern of unusual acylcarnitines. [•] Dicarboxylic and hydroxyl acylcarnitine isomers could be separated. [•] It can be used for high-risk screening and diagnosis of inborn errors of metabolism. [Copyright &y& Elsevier]

Subjects :: *CARNITINE
*DERIVATIZATION
*HYDROPHILIC interaction liquid chromatography
*MASS spectrometry
*INBORN errors of metabolism
*PROPIONYLCARNITINE

Language :: English
ISSN :: 15700232
Volume :: 932
Database :: Academic Search Index
Journal :: Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Publication Type :: Academic Journal
Accession number :: 89342280
Full Text :: https://doi.org/10.1016/j.jchromb.2013.05.028

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