Back to Search
Start Over
CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5.
- Source :
-
Biochemical & Biophysical Research Communications . Jul2013, Vol. 437 Issue 1, p101-107. 7p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] NuRD binds to the promoter of rDNA methyltransferase recruiter TIP5. [•] NuRD enables demethylation of rDNA promoters through repressing TIP5 expression. [•] NuRD deficiency in reprogrammed cells activates TIP5 expression. [•] Reprogramming results in the accumulation of silent state of rRNA genes. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 437
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 89343331
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.06.045