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Synapse Location during Growth Depends on Glia Location.
- Source :
-
Cell . Jul2013, Vol. 154 Issue 2, p337-350. 14p. - Publication Year :
- 2013
-
Abstract
- Summary: Synaptic contacts are largely established during embryogenesis and are then maintained during growth. To identify molecules involved in this process, we conducted a forward genetic screen in C. elegans and identified cima-1. In cima-1 mutants, synaptic contacts are correctly established during embryogenesis, but ectopic synapses emerge during postdevelopmental growth. cima-1 encodes a solute carrier in the SLC17 family of transporters that includes sialin, a protein that when mutated in humans results in neurological disorders. cima-1 does not function in neurons but rather functions in the nearby epidermal cells to correctly position glia during postlarval growth. Our findings indicate that CIMA-1 antagonizes the FGF receptor (FGFR), and does so most likely by inhibiting FGFR’s role in epidermal-glia adhesion rather than signaling. Our data suggest that epidermal-glia crosstalk, in this case mediated by a transporter and the FGF receptor, is vital to preserve embryonically derived circuit architecture during postdevelopmental growth. PaperFlick: Display Omitted [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00928674
- Volume :
- 154
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- 89344417
- Full Text :
- https://doi.org/10.1016/j.cell.2013.06.028