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Roles of levo-tetrahydropalmatine in modulating methamphetamine reward behavior.
- Source :
-
Physiology & Behavior . Jun2013, Vol. 118, p195-200. 6p. - Publication Year :
- 2013
-
Abstract
- Abstract: Levo-tetrahydropalmatine (l-THP), as an alkaloid purified from the traditional Chinese herbal medicine Corydalis and Stephania, has been widely used to produce many traditional Chinese herbal preparations. The effect of l-THP on methamphetamine-induced reward learning still remains unclear although it has been proved to be effective on treating allodynia and drug addiction. This experiment has been designed to examine the effect of l-THP on the acquisition, expression, extinction, and reinstatement of methamphetamine-induced conditioned place preference (CPP) in mice. The results show that methamphetamine (METH) could induce CPP in mice at doses of 0.5mg/kg, 1.0mg/kg and 2.0mg/kg respectively, but l-THP alone could not do so. Meanwhile, l-THP could not induce conditioned place aversion at doses of 1.25mg/kg to 20.0mg/kg in mice, but it could attenuate the acquisition and expression of METH-induced CPP and facilitate the extinction of METH-induced CPP in mice. Besides, l-THP could inhibit the reinstatement of METH-induced CPP at the dose of 10.0mg/kg whether it was given in the extinction training phase or 30min before the reinstatement. These results suggest that l-THP can globally suppress the rewarding properties of METH on all phases of the CPP task and it may have potential effects on the treatment of METH abuse. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00319384
- Volume :
- 118
- Database :
- Academic Search Index
- Journal :
- Physiology & Behavior
- Publication Type :
- Academic Journal
- Accession number :
- 89433852
- Full Text :
- https://doi.org/10.1016/j.physbeh.2013.05.034