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The effects of R683S (G) genetic mutations on the JAK2 activity, structure and stability.
- Source :
-
International Journal of Biological Macromolecules . Sep2013, Vol. 60, p186-195. 10p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] JAK2 R683S (G) mutations are presumed to be a biomarker for MPDs. [•] R683 located in the linker between the N and C lobes of JH2 domain which was important for JAK2 auto-inhibition. [•] Mutations R683G, R683S and R683E increased JAK2 activity and led them into partially unfolded state. [•] This study provides clues in understanding the mechanism of JAK2 R683S (G) mutations caused B-ALL. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 60
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 89436499
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2013.05.029