Estrogen induced concentration dependent differential gene expression in human breast cancer (MCF7) cells: Role of transcription factors.

Highlights: [•] Estradiol (E2) at low dose induced cell proliferation in breast cancer cells. [•] E2 at high concentration induced cell stress in breast cancer cells. [•] Estrogen receptor physically interacts only with a few transcription factors. [•] Differential expression of genes with Oct-1 binding sites increased under stress. [•] Transcription factor binding sites showed distinct spatial distribution on genes. [ABSTRACT FROM AUTHOR]