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Genome-wide methylation profiling demonstrates hypermethylation in maternal leukocyte DNA in preeclamptic compared to normotensive pregnancies.
- Source :
-
Hypertension in Pregnancy . Aug2013, Vol. 32 Issue 3, p257-269. 13p. 3 Charts, 2 Graphs. - Publication Year :
- 2013
-
Abstract
- Objective: To compare genome-wide methylation profiles in maternal leukocyte DNA between normotensive and preeclamptic pregnant women at delivery. Methods: Age, body mass index matched case-control comparison of methylation at 27,578 cytosine- guanine sites in 14,495 genes in maternal leukocyte DNA in women with preeclampsia (PE; n = 14) and normotensive controls ( n = 14). Results: PE was associated with widespread differential methylation favoring hypermethylation. Pathway analysis identified the best matched process as a neuropeptide signaling pathway ( p < 10−5); best matched disease as eclampsia ( p < 9.97 × 10−20). Significantly differentially methylated genes ( GRIN2b. GABRA1. PCDHB7, and BEX1) are associated with seizures. Conclusion: Altered maternal leukocyte DNA methylation is associated with PE at delivery, and differential methylation of certain neuronal genes may explain the risk for eclampsia. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10641955
- Volume :
- 32
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Hypertension in Pregnancy
- Publication Type :
- Academic Journal
- Accession number :
- 89479722
- Full Text :
- https://doi.org/10.3109/10641955.2013.796970