Structural differences between native Hen egg white lysozyme and its fibrils under different environmental conditions.

Highlights: [•] PCA of Raman data discriminates molecular structure of HEWL protein and fibrils. [•] SD of scores in PCA plots determines variability in the structure within a species. [•] Overall structure significantly differs for fibrils grown at different pH values. [•] Overall structure of fibrils grown at different pH values in Cu(II) has similarity. [•] Presence of Cu(II), inhibits the formation β-sheet component in HEWL fibrils. [ABSTRACT FROM AUTHOR]