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Prognostic Significance of Extracellular Matrix Degrading Enzymes-Cathepsin L and Matrix Metalloproteases-2 [MMP-2] in Human Pancreatic Cancer.
- Source :
-
Cancer Investigation . Aug2013, Vol. 31 Issue 7, p461-471. 11p. 2 Color Photographs, 9 Charts, 1 Graph. - Publication Year :
- 2013
-
Abstract
- In the present study, we assessed the expression of extracellular matrix (ECM) degrading proteases-cathepsin L and matrix metalloprotease-2 (MMP-2) in pancreatic cancer tissue and correlated their levels with clinicopathological parameters and survival. Both the proteases were expressed in the majority of the tumor tissues examined. Staining intensity of cathepsin L was significantly higher in the tumor stroma compared to tumor epithelium while MMP-2 staining showed no such difference. Both proteases showed correlation with some of the clinicopathological parameters but only cathepsin L expression in tumor epithelium predicted a poor prognosis for the disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07357907
- Volume :
- 31
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Cancer Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 89566590
- Full Text :
- https://doi.org/10.3109/07357907.2013.820318