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Systematic assignment of NMR spectra of 5-substituted-4-thiopyrimidine nucleosides.
- Source :
-
Magnetic Resonance in Chemistry . Sep2013, Vol. 51 Issue 9, p523-529. 6p. - Publication Year :
- 2013
-
Abstract
- Unambiguous characterization of 5-substituted-4-thiopyrimidine nucleosides (ribonucleosides and 2'-deoxynucleosides) was performed using NMR spectroscopy. Assignments of all proton and carbon signals of 5-bromo-4-thiouridine and related nucleosides were systematically carried out and firmly established by COSY and HMQC techniques. The NMR data of various 4-thiopyrimidine nucleosides are compared, and the key contributing factors discussed. The approach presented here is applicable to other modified nucleosides and nucleotides, as well as nucleobases. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07491581
- Volume :
- 51
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Magnetic Resonance in Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 89599498
- Full Text :
- https://doi.org/10.1002/mrc.3980