Mitochondria: sensors and mediators of innate immune receptor signaling.

Highlights: [•] Mitochondrial fission/fusion and mitophagy regulators modulate RLR responses. [•] NLRP3 activation is dependent on mitochondrial localization and mROS. [•] Cyclic AMP activates the NLRP3 inflammasome via the calcium-sensing receptor. [•] LPS increases succinate to stabilize HIF-1α-mediated regulation of IL-1β. [•] ECSIT interacts with TRIM59 negatively regulating TLR signaling. [ABSTRACT FROM AUTHOR]