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The spectrum of MOG autoantibody-associated demyelinating diseases.
- Source :
-
Nature Reviews Neurology . Aug2013, Vol. 9 Issue 8, p455-461. 7p. - Publication Year :
- 2013
-
Abstract
- Myelin oligodendrocyte glycoprotein (MOG) has been identified as a target of demyelinating autoantibodies in animal models of inflammatory demyelinating diseases of the CNS, such as multiple sclerosis (MS). Numerous studies have aimed to establish a role for MOG antibodies in patients with MS, although the results have been controversial. Cell-based immunoassays using MOG expressed in mammalian cells have demonstrated the presence of high-titre MOG antibodies in paediatric patients with acute disseminated encephalomyelitis, MS. aquaporin-4-seronegative neuromyelitis optica, or isolated optic neuritis or transverse myelitis, but only rarely in adults with these disorders. These studies indicate that MOG antibodies could be associated with a broad spectrum of acquired human CNS demyelinating diseases. This Review article discusses the current I terature on MOG antibodies, their potential clinical relevance, and their role in the pathogenesis of MOG antibody-associated demyelinating disorders. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17594758
- Volume :
- 9
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Nature Reviews Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 89798013
- Full Text :
- https://doi.org/10.1038/nrneurol.2013.118