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Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies.
- Source :
-
Biochemical & Biophysical Research Communications . Aug2013, Vol. 438 Issue 2, p249-256. 8p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] We report interactions of Toll-like receptors (TLRs) with COX enzymes in vivo. [•] COX-2 was broadly induced by LPS (TLR4) but more locally by poly(I:C) (TLR3). [•] COX-1/2 deletion modified the response to TLR activation in a TLR-specific manner. [•] COX-2 deletion enhanced interferon responses to viral-type TLR3/7/9 ligands. [•] COX-2 inhibition could provide a novel anti-viral therapeutic strategy. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 438
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 89824800
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.07.006