Many ways lead to Rome: a glance at the multiple immunological pathways underlying atopic dermatitis.

In this article, the author focuses on the multiple immunological pathways underlying atopic dermatitis (AD). He states that AD represents a genetic complex disease where gene-gene interactions and gene-environment interactions form a highly complex mosaic. He mentions that AD has a deep impact on the gene expression of filaggrin (FLG) and proteins of epidermal barrier. He discusses the lack of appropriate secretion of antimicrobial peptides (AMP) in inflamed skin of AD.