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Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy.
- Source :
-
Clinical Ophthalmology . 2013, Vol. 7, p1339-1345. 7p. - Publication Year :
- 2013
-
Abstract
- Purpose: To describe immunohistopathological findings in autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV). Methods: An enucleated eye specimen from a patient with Stage V ADNIV was examined using standard histopathological methods and lymphocyte markers. Results: A c.731T>C CAPN5 mutation resulted in a p.Leu244Pro substitution in calpain-5. The eye showed exudative retinal detachment and neovascularization, intraocular fibrosis, and features of phthisis bulbi. Chronic inflammatory CD3-positive cell infiltrates were identified throughout the uvea, vitreous and retina, consistent with chronic uveitis. Conclusion: Mutations in CAPN5 trigger autoimmune uveitis characterized by inflammatory T-cells and severe neovascularization. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11775467
- Volume :
- 7
- Database :
- Academic Search Index
- Journal :
- Clinical Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 89892981
- Full Text :
- https://doi.org/10.2147/OPTH.S46450