MicroRNAs in Metabolism and Metabolic Diseases.

Authors :: ROTTIERS, V.
NAJAFI-SHOUSHTARI, S. H.
KRISTO, F.
GURUMURTHY, S.
L. ZHONG
Y. LI
COHEN, D. E.
GERSZTEN, R. E.
BARDEESY, N.
MOSTOSLAVSKY, R.
NÄÄR, A. M.
Source :: Cold Spring Harbor Symposia on Quantitative Biology. 2011, Vol. 76, p225-233. 9p.
Publication Year :: 2011
Abstract: The article discusses a study which showed that sterol regulatory element-binding proteins (SREBPs) activate many genes in the one-carbon cycle to provide S-adeosylmethionine (SAMe), the major cellular methyl donor and key cofactor for the synthesis of the membrane phospholipid phosphatidylcholine. It suggests the cooperation between SREBP-2 and its intronic miRNA miR-33a indicating an important function of miR-33 in inhibiting proteins counteracting SREBP-dependent activities.