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CDK8 as the STAT1 serine 727 kinase?
- Source :
-
JAK-STAT . Jul-Sep2013, Vol. 2 Issue 3, pe24275-1-e24275-4. 4p. - Publication Year :
- 2013
-
Abstract
- Whereas cytokine-induced tyrosine phosphorylation of STAT (signal transducer and activator of transcription) proteins by JAK kinases has been well studied, much less is known about STAT-specific serine kinases and their signal-dependent regulation. The paper by Joanna Bancerek and colleagues published recently in Immunity reports that upon interferon-γ (IFNγ) stimulation of cells the chromatin-associated cyclindependent kinase 8 (CDK8) phosphorylates the regulatory serine residue 727 in the transactivation domain of STAT1. The authors state that the CDK8 module of the Mediator complex is a key component in the STAT1 signal pathway, linking serine phosphorylation to genespecific transcriptional events [ABSTRACT FROM AUTHOR]
- Subjects :
- *TYROSINE
*PHOSPHORYLATION
*CYTOKINES
*CHROMATIN
*GENE regulatory networks
Subjects
Details
- Language :
- English
- ISSN :
- 21623988
- Volume :
- 2
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- JAK-STAT
- Publication Type :
- Academic Journal
- Accession number :
- 89978370
- Full Text :
- https://doi.org/10.4161/jkst.24275