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Competitive displacement of cofilin can promote actin filament severing.
- Source :
-
Biochemical & Biophysical Research Communications . Sep2013, Vol. 438 Issue 4, p728-731. 4p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] Myosin and phalloidin are predicted to modulate cofilin-mediated filament severing. [•] Competitive displacement of bound cofilin by myosin and phalloidin is measured. [•] Competition can promote filament severing, depending on initial cofilin occupancy. [•] Maximal severing occurs near half cofilin occupancy, even with competitors present. [•] We propose a general “severodyne” framework to describe cofilin regulation. [Copyright &y& Elsevier]
- Subjects :
- *MICROFILAMENT proteins
*ACTIN
*MYOSIN
*PHALLOIDINE
*XENOPUS
*N-ethylmaleimide
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 438
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 90066856
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.07.109