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Modeling interleukin-2-based immunotherapy in AIDS pathogenesis.
- Source :
-
Journal of Theoretical Biology . Oct2013, Vol. 335, p57-78. 22p. - Publication Year :
- 2013
-
Abstract
- Abstract: In this paper, we sought to identify the CD4+ T-cell dynamics in the course of HIV infection in response to continuous and intermittent intravenous courses of interleukin-2 (IL-2), the principal cytokine responsible for progression of CD4+ T-lymphocytes from the G1 to the S phase of the cell cycle. Based on multivariate regression models, previous literature has concluded that the increase in survival of CD4+ T-cell appears to be the critical mechanism leading to sustained CD4+ T-cell levels in HIV-infected patients receiving intermittent IL-2 therapy. Underscored by comprehensive mathematical modeling, a major finding of the present work is related to the fact that, rather than due to any increase in survival of CD4+ T-cells, the expressive, selective and sustained CD4+ T-cell expansions following IL-2 administration may be related to the role of IL-2 in modulating the dynamics of Fas-dependent apoptotic pathways, such as activation-induced cell death (AICD) or HIV-specific apoptotic routes triggered by viral proteins. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00225193
- Volume :
- 335
- Database :
- Academic Search Index
- Journal :
- Journal of Theoretical Biology
- Publication Type :
- Academic Journal
- Accession number :
- 90067575
- Full Text :
- https://doi.org/10.1016/j.jtbi.2013.06.019