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Evaluation of stationary phases based on silica hydride for the analysis of drugs of abuse.
- Source :
-
Journal of Separation Science . Sep2013, Vol. 36 Issue 17, p2760-2766. 7p. - Publication Year :
- 2013
-
Abstract
- Several stationary phases based on silica hydride were evaluated as possible separation media for drugs of abuse. In the RP mode both a C18 and a phenyl column were tested using ACN/water and methanol/water mobile phases with formic acid or ammonium formate as modifiers. Detection was performed using MS, so separation of isobaric species was a factor in selecting the column, mobile phase composition, and gradient. A number of sample preparation procedures were also included as part of determining the most appropriate experimental protocol on these types of stationary phases. Morphine was used as a model for developing a protocol that would be suitable for the analysis of hydrophilic drugs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16159306
- Volume :
- 36
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Journal of Separation Science
- Publication Type :
- Academic Journal
- Accession number :
- 90081610
- Full Text :
- https://doi.org/10.1002/jssc.201300377