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Intrathecal oligoclonal IgG synthesis in multiple sclerosis.
- Source :
-
Journal of Neuroimmunology . Sep2013, Vol. 262 Issue 1/2, p1-10. 10p. - Publication Year :
- 2013
-
Abstract
- Abstract: The diagnosis of multiple sclerosis is based on dissemination in time and space. Before 2010 lack of evidence for dissemination in space could be substituted by a paraclinical test, cerebrospinal fluid (CSF) oligoclonal bands (OCBs). The present meta-analysis (13,467 patients) shows that the diagnostic specificity of OCB drops from 94% to 61% if inflammatory etiologies are considered. Importantly, this was not caused by poor laboratory practice. This review on CSF OCB further illustrates the conceptional problem of substituting dissemination in space with a biomarker. The potential prognostic value of intrathecal OCB will need to be tested prospectively. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01655728
- Volume :
- 262
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 90092710
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2013.06.014