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Chromosomal region of the cystic fibrosis gene in yeast artificial chromosomes: A model for human...
- Source :
-
Science . 10/5/1990, Vol. 250 Issue 4977, p94. 5p. 20 Black and White Photographs, 3 Diagrams, 1 Chart. - Publication Year :
- 1990
-
Abstract
- Investigates a general strategy for cloning and mapping large regions of human DNA with yeast artificial chromosomes (YACs). Use of polymerase chain reaction to detect sequence-tagged sites (STSs); Use of method in region of human chromosome 7 containing cystic fibrosis (CF) gene; Analysis of YAC clones; Assembly of contiguous map; Construction of individual YACs `in vivo' by meiotic recombination.
- Subjects :
- *DNA
Subjects
Details
- Language :
- English
- ISSN :
- 00368075
- Volume :
- 250
- Issue :
- 4977
- Database :
- Academic Search Index
- Journal :
- Science
- Publication Type :
- Academic Journal
- Accession number :
- 9010291254
- Full Text :
- https://doi.org/10.1126/science.2218515