Neural processing of itch.

Highlights: [•] There are histamine-dependent and -independent types of itch. [•] Molecular detectors of pruritogens include Mrgprs, PARs, and many others. [•] Spinal transmitters include gastrin releasing peptide and natriuretic polypeptide B. [•] Pruritogen-sensitive sensory neurons usually also respond to pain-producing stimuli. [•] Pruritogen-responsive sensory neurons connect to an itch-specific central pathway. [ABSTRACT FROM AUTHOR]