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A mouse model of the aniridia-Wilms tumor deletion syndrome.
- Source :
-
Science . 11/9/1990, Vol. 250 Issue 4982, p823. 5p. 7 Black and White Photographs, 2 Charts. - Publication Year :
- 1990
-
Abstract
- Describes research in which the homologous chromosomal region in the mouse genome was mapped and an animal model was defined in order to study the WAGR syndrome in humans, which consists of aniridia, Wilms tumor, genitourinary formations and mental retardation. Localization of nine evolutionarily conserved DNA clones; Deletion of three clones related to aniridia and Wilms tumor susceptibility; Possible role of AN2 gene product.
- Subjects :
- *CANCER research
Subjects
Details
- Language :
- English
- ISSN :
- 00368075
- Volume :
- 250
- Issue :
- 4982
- Database :
- Academic Search Index
- Journal :
- Science
- Publication Type :
- Academic Journal
- Accession number :
- 9012100361
- Full Text :
- https://doi.org/10.1126/science.2173141