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Increased ratio of glutamate/glutamine to creatine in the right hippocampus contributes to depressive symptoms in patients with epilepsy.
- Source :
-
Epilepsy & Behavior . Oct2013, Vol. 29 Issue 1, p144-149. 6p. - Publication Year :
- 2013
-
Abstract
- Abstract: Purpose: Our study aimed to investigate whether the glutamatergic system in the hippocampus is correlated with depressive symptoms in patients with epilepsy. Methods: Fifty patients with epilepsy were recruited and divided into three groups on the basis of their Hamilton Depression Rating Scale (HAMD) scores. Single-voxel proton magnetic resonance spectroscopy (1H-MRS) was carried out. Pearson correlation analysis and multiple linear regression analysis were performed to investigate any correlation between the variables of hippocampal metabolites and HAMD scores. Results: Proton magnetic resonance spectroscopy analysis showed that the ratio of glutamate/glutamine to creatine (Glx/Cr) in the right hippocampus was significantly increased in patients with moderate depression and correlated positively with HAMD scores. Multiple linear regression analysis showed that the ratio of Glx/Cr in the right hippocampus was an independent risk factor relating to depressive symptoms in patients with epilepsy. Conclusion: A disturbance of the hippocampal glutamatergic system may be involved in the pathogenesis of depression in epilepsy. [Copyright &y& Elsevier]
- Subjects :
- *GLUTAMIC acid
*GLUTAMINE
*CREATINE
*HIPPOCAMPUS (Brain)
*MENTAL depression
*EPILEPSY
Subjects
Details
- Language :
- English
- ISSN :
- 15255050
- Volume :
- 29
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Epilepsy & Behavior
- Publication Type :
- Academic Journal
- Accession number :
- 90160737
- Full Text :
- https://doi.org/10.1016/j.yebeh.2013.07.004