Differential regulation of MHCII genes by PRMT6, via an AT-hook motif of RFX5.

Highlights: [•] An evolutionarily conserved AT-hook motif is present in the MHCII regulator RFX5. [•] The AT-hook motif is necessary for proper HLA-DQ, but not HLA-DR expression. [•] Defective expression of HLA-DQ is due to defective transcription of the HLA-DQA chain. [•] PRMT6 methylates the AT-hook and downregulates HLA-DQ expression. [ABSTRACT FROM AUTHOR]