Back to Search
Start Over
Dipeptides promote folding and peptide binding of MHC class I molecules.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America . 9/17/2013, Vol. 110 Issue 38, p15383-15388. 6p. - Publication Year :
- 2013
-
Abstract
- MHC class I molecules bind only those peptides with high affinity that conform to stringent length and sequence requirements. We have now investigated which peptides can aid the in vitro folding of class I molecules, and we find that the dipeptide glycyl-leucine efficiently supports the folding of HLA-A*02:01 and H-2Kb into a peptide-receptive conformation that rapidly binds high-affinity peptides. Treatment of cells with glycyl-leucine induces accumulation of peptide-receptive H-Kb and HLA-A*02:01 at the surface of cells. Other dipeptides with a hydrophobic second amino acid show similar enhancement effects. Our data suggest that the dipeptides bind into the F pocket like the C-terminal amino acids of a high-affinity peptide. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIPEPTIDES
*PEPTIDES
*LEUCINE
*AMINO acids
*MOLECULES
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 110
- Issue :
- 38
- Database :
- Academic Search Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 90334507
- Full Text :
- https://doi.org/10.1073/pnas.1308672110