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Pharmacological Treatment of Dementia: A Scoping Review of Systematic Reviews.
- Source :
-
Dementia & Geriatric Cognitive Disorders . Sep2013, Vol. 36 Issue 3/4, p211-228. 18p. 1 Diagram, 3 Charts. - Publication Year :
- 2013
-
Abstract
- Background: Until now, multiple reviews on the pharmacological treatment of dementia have been published. Methods: We performed a scoping review to summarize research findings and to identify gaps in the existing literature. We searched the literature and assessed the risk of bias of the included reviews. A team of clinical experts assessed the fields in which more research is necessary. Fifty-five reviews with a low risk of bias were included, most of them concerning the treatment of cognitive decline (n = 16) and behavioral symptoms (n = 10) in Alzheimer's disease (AD). For cognitive impairment, cholinesterase inhibitors (n = 13) and memantine (n = 7) were described most frequently. Little information was found about the treatment of depression in dementia. Conclusions: For many current treatments, there is sufficient evidence. New research should focus on the symptomatic treatment of the earliest and most salient complaints in AD as well as on disease-modifying interventions acting at the level of the amyloid cascade. © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALZHEIMER'S disease
*CINAHL database
*DEMENTIA
*MENTAL depression
*DRUGS
*EXPERTISE
*INFORMATION storage & retrieval systems
*MEDICAL databases
*MEDICAL information storage & retrieval systems
*PSYCHOLOGY information storage & retrieval systems
*MEDICAL personnel
*MEDLINE
*SYSTEMATIC reviews
*EVIDENCE-based medicine
*AGITATION (Psychology)
*PROFESSIONAL practice
*CONCEPT mapping
*SYMPTOMS
Subjects
Details
- Language :
- English
- ISSN :
- 14208008
- Volume :
- 36
- Issue :
- 3/4
- Database :
- Academic Search Index
- Journal :
- Dementia & Geriatric Cognitive Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 90374921
- Full Text :
- https://doi.org/10.1159/000353892