Oxidative aliphatic carbon–carbon bond cleavage reactions.

Highlights: [•] Metalloenzyme-catalyzed aliphatic carbon–carbon bond cleavage reactions recently identified. [•] Substrates vary in terms of their O2 reactivity in the absence of enzyme. [•] Reaction pathways depend on the nature of the substrate; metal versus substrate reactivity with O2. [•] Regioselectivity of carbon–carbon bond cleavage influenced by nature of metal ion. [•] Model systems providing insight into structure/reactivity relationships. [ABSTRACT FROM AUTHOR]