Release of biologically active kinin peptides, Met-Lys-bradykinin and Leu-Met-Lys-bradykinin from human kininogens by two major secreted aspartic proteases of Candida parapsilosis.

Highlights: [•] Candida parapsilosis secrete two aspartic proteases which cleave human kininogens. [•] These proteases release two kinins, Met-Lys-bradykinin and Leu-Met-Lys-bradykinin. [•] Met-Lys-bradykinin and Leu-Met-Lys-bradykinin interact with kinin receptors B2. [•] These kinins stimulate endothelial cells to the secretion of interleukins 1β and 6. [•] In plasma, these kinins are converted into bradykinin and its des-Arg derivative. [ABSTRACT FROM AUTHOR]