Biological insights into BRAFV600 mutations in melanoma patient.

The article discusses the role of BRAF gene mutations in patients with melanoma. Evidence from studies conducted suggested that BRAF mutations are unlikely to occur as homozygous alterations in a sample of patients with melanoma, with gene amplification contributing to mask the heterozygous state. BRAF's key role in the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling pathway is also discussed.