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The Age-related Maculopathy Susceptibility 2 Polymorphism and Polypoidal Choroidal Vasculopathy in Asian Populations: A Meta-Analysis.
- Source :
-
Ophthalmology . Oct2013, Vol. 120 Issue 10, p2051-2057. 7p. - Publication Year :
- 2013
-
Abstract
- Objective: To assess the role of the age-related maculopathy susceptibility 2 (ARMS2) A69S polymorphism as a risk factor for polypoidal choroidal vasculopathy (PCV) in Asian populations. Methods: We performed a meta-analysis of the association of the A69S variant with PCV in Asian populations using data available from 14 case-control studies involving 6552 subjects. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed- and random-effects models. Sensitivity analysis also was performed. Main Outcome Measures: Understanding the relationship between the A69S variant and PCV is essential to provide new insights into pathophysiology and potential targets for intervention of PCV. Results: The pooled OR in random-effects models for genotype TG+TT versus wild homozygous genotype GG is 2.39 (95% CI, 1.98–2.89), the OR of heterozygous genotype TG versus GG is 1.66 (95% CI, 1.37–2.00), the OR of homozygous genotype TT versus GG is 4.74 (95% CI, 3.94–5.70), and the OR of allele T versus G is 2.14 (95% CI, 1.79–2.56). A sensitivity analysis indicated the robustness of our findings. Conclusions: Our analysis provides evidence that the A69S variant is associated with an increased risk of PCV in Asian populations. The variant of A69S could be a promising genetic biomarker of PCV. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01616420
- Volume :
- 120
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 90510799
- Full Text :
- https://doi.org/10.1016/j.ophtha.2013.03.026