The Age-related Maculopathy Susceptibility 2 Polymorphism and Polypoidal Choroidal Vasculopathy in Asian Populations: A Meta-Analysis.

Objective: To assess the role of the age-related maculopathy susceptibility 2 (ARMS2) A69S polymorphism as a risk factor for polypoidal choroidal vasculopathy (PCV) in Asian populations. Methods: We performed a meta-analysis of the association of the A69S variant with PCV in Asian populations using data available from 14 case-control studies involving 6552 subjects. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed- and random-effects models. Sensitivity analysis also was performed. Main Outcome Measures: Understanding the relationship between the A69S variant and PCV is essential to provide new insights into pathophysiology and potential targets for intervention of PCV. Results: The pooled OR in random-effects models for genotype TG+TT versus wild homozygous genotype GG is 2.39 (95% CI, 1.98–2.89), the OR of heterozygous genotype TG versus GG is 1.66 (95% CI, 1.37–2.00), the OR of homozygous genotype TT versus GG is 4.74 (95% CI, 3.94–5.70), and the OR of allele T versus G is 2.14 (95% CI, 1.79–2.56). A sensitivity analysis indicated the robustness of our findings. Conclusions: Our analysis provides evidence that the A69S variant is associated with an increased risk of PCV in Asian populations. The variant of A69S could be a promising genetic biomarker of PCV. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. [Copyright &y& Elsevier]