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RSK2-induced stress tolerance enhances cell survival signals mediated by inhibition of GSK3β activity.
- Source :
-
Biochemical & Biophysical Research Communications . Oct2013, Vol. 440 Issue 1, p112-118. 7p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] We demonstrated a novel function of RSK2 in stress tolerance. [•] RSK2 deficiency enhanced apoptosis by calcium stress. [•] RSK2-mediated GSK3β phosphorylation at serine 9 increased calcium-induced stress tolerance. [•] Calcium stress-induced apoptosis inhibited by adding back of RSK2 into RSK2−/− MEFs. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 440
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 91092439
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.09.042