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Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival.
- Source :
-
British Journal of Cancer . 2/24/2003, Vol. 88 Issue 4, p574-578. 5p. - Publication Year :
- 2003
-
Abstract
- Recent studies have demonstrated cyclooxygenase 2 (COX-2) overexpression in various human malignancies, especially in breast cancer, where COX-2 turned out to be a predictor of poor survival. To evaluate the relation of COX-2 and Ep-CAM overexpression and its prognostic significance, we performed a retrospective study on 212 breast cancer patients with a median follow-up time of 10.5 years. Overexpression of COX-2 in tumour tissue samples was assessed by immunohistochemistry. COX-2 overexpression was found in 48.6% of the tumour samples and was predictive for poor disease-free and overall survival. Univariate analysis revealed a strong correlation between COX-2 and Ep-CAM overexpression (P=0.009). Concurrent COX-2 and Ep-CAM overexpression was present in 21.7% of tumour specimens and had an additive negative impact on disease-free and overall survival. Determination of both tumour markers should help in guiding new therapeutic strategies in patients with invasive breast cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CYCLOOXYGENASE 2
*CANCER prognosis
Subjects
Details
- Language :
- English
- ISSN :
- 00070920
- Volume :
- 88
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- British Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 9124881
- Full Text :
- https://doi.org/10.1038/sj.bjc.6600741